SREBF1 cDNA (ANA00013-P001)

• Product Number: ANA00013-P001
• Name: SREBF1 cDNA (ANA00013-P001)
• Tag: None
• NCBI Gene Id: 6720
• Alias Symbols: HMD, IFAP2, SREBP1, bHLHd1
• Reference: Motoyama,K., (2006) Biochem. Biophys. Res. Commun. 342 (1), 354-360
• Description of Target: SREBF1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
• Protein Interactions: UBC; ERLIN2; FBXW7; SMARCD3; HSP90AA1; SUMO1; ATXN1L; INSIG2; SCAP; ATXN1; LMNA; INSIG1; EGF; SREBF2; SREBF1; ZBTB7A; ZBTB7C; SUMO2; MED6; MED13; MED12; MED24; MED26; MED17; MED23; MED14; USF1; MED1; GSK3B; CREBBP; CDK8; MED25; MED15; MED7; MED21; SIRT1;
• Reconstitution and Storage: Already in solution (1 ug/ul). For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
• Uniprot ID: P36956
• Protein Name: Sterol regulatory element-binding protein 1
• Protein Accession #: NP_004167
• Nucleotide Accession #: NM_004176
• Gene Symbol: SREBF1