| Sku |
AAPS31602 |
| Price |
$99.00 |
| Name |
MDM4 Peptide (AAPS31602) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
MDM4 |
| Alias symbols |
DKFZp781B1423, MDMX, MGC132766, MRP1, HDMX |
| Gene id |
4194 |
| Description of target |
MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. It inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
O15151 |
| Protein accession num |
NP_002384 |
| Nucleotide accession num |
NM_002393 |
| Protein size |
490 amino acids |
| Molecular weight |
55kDa |
| Application |
WB |
| Partner proteins |
CDK1,E2F1,MDM2,MDM2,RB1,USP7,AKT1,ARF1,ATM,CASP3,CDK1,CHEK1,CHEK2,CSNK1A1,E2F1,EP300,MDM2,RB1,SFN,SMAD3,TP53,TP73,UBE2D1,USP7,YWHAB,YWHAE,YWHAG,YWHAH,YWHAQ,YWHAZ,CDKN2A,E2F1,EP300,MDM2,SMAD3,SMAD4,TP53,UBE2D1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Danovi,D., et al., (2004) Mol. Cell. Biol. 24 (13), 5835-5843 |
| Description |
This is a synthetic peptide designed for use in combination with anti-MDM4 antibody (Catalog #: AVARP06007_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
