SMARCE1 Peptide (AAPS05009)

Data Sheet
 
Sku AAPS05009
Price $99.00
Name SMARCE1 Peptide (AAPS05009)
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Size 100 ug
Gene symbol SMARCE1
Alias symbols BAF57
Gene id 6605
Description of target SMARCE1 is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.
Swissprot id Q969G3
Protein accession num NP_003070
Nucleotide accession num NM_003079
Protein size 411 amino acids
Molecular weight 47kDa
Application IHC, WB
Partner proteins DISC1,tax,ARID2,BAZ1B,BRMS1,ESR1,ESR2,NCOA1,NCOA2,NCOA3,NR3C1,RCOR1,RELB,SMAD1,SMARCA4,SRC,ACTB,ACTL6A,ARID1A,BAZ1B,ESR1,ESR2,Esr1,GATA1,KLF1,MECP2,NCOA1,NR3C1,RELB,SMARCA2,SMARCA4,SMARCB1,SMARCC1,SMARCC2,STAT2,TFE3
Quality control The peptide is characterized by mass spectroscopy
Key reference Chen,J. (2005) Mol. Cell. Biol. 25 (20), 9016-9027
Description This is a synthetic peptide designed for use in combination with anti-SMARCE1 antibody (Catalog #: ARP38224_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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