| Sku |
AAP58642 |
| Old sku |
AAPP35779 |
| Price |
$99.00 |
| Name |
MVP Peptide - N-terminal region (AAP58642) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
MVP |
| Alias symbols |
LRP, VAULT1 |
| Gene id |
9961 |
| Description of target |
MVP is required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. MVP down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. MVP down-regulates SRC activity and signaling through MAP kinases.This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. |
| Swissprot id |
Q14764 |
| Protein accession num |
NP_005106 |
| Nucleotide accession num |
NM_005115 |
| Protein size |
893 amino acids |
| Molecular weight |
98kDa |
| Application |
WB |
| Partner proteins |
YBX1,ESR1,PARP4,PTEN,PTPN11,SLC2A4,ESR1,PARP4,PTEN |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
de (2008) Cytometry B Clin Cytom 74 (3), 163-168 |
| Description |
This is a synthetic peptide designed for use in combination with anti-MVP antibody (Catalog #: ARP58642_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
