Sku |
AAP58283 |
Old sku |
AAPP32882 |
Price |
$99.00 |
Name |
H2AFY Peptide - middle region (AAP58283) |
Purchase info |
To purchase this peptide:
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|
Size |
100 ug |
Gene |
H2AFY |
Alias symbols |
H2A.y, H2A/y, H2AF12M, H2AFJ, MACROH2A1.1, mH2A1, macroH2A1.2 |
Gene id |
9555 |
Description of target |
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. H2AFY is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Swissprot id |
O75367 |
Protein accession num |
NP_001035248 |
Nucleotide accession num |
NM_001040158 |
Protein size |
371 amino acids |
Molecular weight |
39kDa |
Application |
WB |
Partner proteins |
SPOP,BRCA1,DEK,HDAC1,HSPA4,PARP1,PHF14,RAN,RCC1,TOP1,WDR77,XRCC5 |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Bernstein,E., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (5), 1533-1538 |
Description |
This is a synthetic peptide designed for use in combination with anti-H2AFY antibody (Catalog #: ARP58283_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
|
Tips |
See our General FAQ page. |
Availability |
In Stock |