| Sku |
AAP58175 |
| Old sku |
AAPP32627 |
| Price |
$99.00 |
| Name |
PSMC3 Peptide (AAP58175) |
| Purchase info |
To purchase this peptide:
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|
| Size |
100 ug |
| Gene |
PSMC3 |
| Alias symbols |
MGC8487, TBP1 |
| Gene id |
5702 |
| Description of target |
PSMC3 is a subunit of the 26S proteasome. 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
P17980 |
| Protein accession num |
NP_002795 |
| Nucleotide accession num |
NM_002804 |
| Protein size |
439 amino acids |
| Molecular weight |
49kDa |
| Application |
WB |
| Partner proteins |
CDKN2A,ATXN1,CDKN2A,NDRG1,PSMC3,PSMC3IP,PSMC4,PSMC5,STX11,TRAF6,VHL,CDKN2A,EPAS1,HIF1A,HTR1E,PAAF1,PMS2,PSMC4,PSMC5,PSMD10,PSMD13,PSMD6,PSMD7,STX11,TRAF6,TXNRD2,UCHL5,USP14,VHL |
| Subunit |
6A |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Pollice,A., (2007) Oncogene 26 (35), 5154-5162 |
| Description |
This is a synthetic peptide designed for use in combination with anti-PSMC3 antibody (Catalog #: ARP58175_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
