| Sku |
AAP58127 |
| Old sku |
AAPP32560 |
| Price |
$99.00 |
| Name |
RUNX1T1 Peptide - middle region (AAP58127) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
RUNX1T1 |
| Alias symbols |
AML1T1, CBFA2T1, CDR, ETO, MGC2796, MTG8, MTG8b, ZMYND2 |
| Gene id |
862 |
| Description of target |
RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene. |
| Swissprot id |
B2R6I9 |
| Protein accession num |
NP_004340 |
| Nucleotide accession num |
NM_004349 |
| Protein size |
577 amino acids |
| Molecular weight |
64kDa |
| Application |
IHC, WB |
| Partner proteins |
CBFA2T2,HDAC1,HDAC3,NCOR1,SIN3A,TCF12,TCF12,TCF3,TCF4,ABI3,ATN1,BCL6,C19orf57,CBFA2T3,GFI1,HDAC1,HDAC3,HDAC8,HSP90AA1,ID1,ID3,KPNA1,KPNB1,NCOR1,NCOR2,NECAB2,PRKAR2A,RUNX1T1,SIN3A,TAF9B,TCF3,TCF4,UBQLN4,WBP11,ZBTB16,ABI3,C19orf57,CBFA2T2,CBFA2T3,CEP170L,GFI1,HDAC1,HDAC2,HDAC3,HDAC8,KPNA1,KPNB1,NCOR1,NCOR2,NECAB2,OTUD4,PRKAR2A,RUNX1T1,SIN3A,TAF9B,THRAP3,VDR,WBP11,ZBTB16 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Salat,D., (2008) Mol. Cell. Biol. 28 (10), 3502-3512 |
| Description |
This is a synthetic peptide designed for use in combination with anti-RUNX1T1 antibody (Catalog #: ARP58127_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
