RTKN Peptide - middle region (AAP56211)

Data Sheet
Sku AAP56211
Old sku AAPP38130
Price $99.00
Name RTKN Peptide - middle region (AAP56211)
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Size 100 ug
Gene id 6242
Description of target RTKN mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. RTKN may play a novel role in the organization of septin structures.This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Swissprot id Q9BST9
Protein accession num NP_001015055
Nucleotide accession num NM_001015055
Protein size 563 amino acids
Molecular weight 63kDa
Application WB
Quality control The peptide is characterized by mass spectroscopy
Key reference Sudo,K., (2007) Hum. Mutat. 28 (10), 1005-1013
Description This is a synthetic peptide designed for use in combination with anti-RTKN antibody (Catalog #: ARP56211_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days

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