NDP Peptide - middle region (AAP56082)

Data Sheet
 
Sku AAP56082
Old sku AAPP37547
Price $99.00
Name NDP Peptide - middle region (AAP56082)
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Size 100 ug
Gene symbol NDP
Alias symbols EVR2, FEVR, ND
Gene id 4693
Description of target NDP activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. NDP plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. NDP acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). NDP may be involved in a pathway that regulates neural cell differentiation and proliferation. NDP is the genetic locus identified as harboring mutations that result in Norrie disease. Norrie disease is a rare genetic disorder characterized by bilateral congenital blindness that is caused by a vascularized mass behind each lens due to a maldeveloped retina (pseudoglioma). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-94 AL034370.1 53727-53820 c 95-1761 X65882.1 1-1667 1762-1935 BE139596.1 1-174 c
Swissprot id Q00604
Protein accession num NP_000257
Nucleotide accession num NM_000266
Protein size 133 amino acids
Molecular weight 15kDa
Application IHC, WB
Partner proteins NDP
Quality control The peptide is characterized by mass spectroscopy
Key reference Khan,A.O., (2008) Ophthalmology 115 (4), 730-733
Description This is a synthetic peptide designed for use in combination with anti-NDP antibody (Catalog #: ARP56082_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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