MLH1 Peptide - N-terminal region (AAP56076)

Data Sheet
 
Sku AAP56076
Old sku AAPP37541
Price $99.00
Name MLH1 Peptide - N-terminal region (AAP56076)
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Size 100 ug
Gene MLH1
Alias symbols COCA2, FCC2, HNPCC, HNPCC2, MGC5172, hMLH1
Gene id 4292
Description of target This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC.This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot id P40692
Protein accession num NP_000240
Nucleotide accession num NM_000249
Protein size 756 amino acids
Molecular weight 84kDa
Application WB
Partner proteins E2F1,E2F4,BLM,EXO1,EXO1,MBD4,MLH3,MSH4,MYC,PMS1,PMS2,AP2B1,BLM,BRCA1,CASP3,EXO1,FRMD6,MBD4,MLH3,MSH4,MYC,PMS1,PMS2,RAD9A,TRIM29,UBOX5,ZC3H11A,AIFM1,AMOT,AP2B1,ATAD3A,ATAD3B,ATM,ATP5A1,BLM,BRCA1,BRIP1,DOCK7,EXO1,EXO1,FRMD6,KPNA2,KPNB1,MBD4,MLH3,MRE11A,MSH2,MSH3,MSH4,MSH6,MTMR15,MYC,NBN,NTG2,PIK3C2A,PMS1,PMS2,PPP2R1A,PPP2R2A,PPP2R2B,PPP2R2D,PPP3CB,PPP3CC,PRKDC,PSD3,PYGB,RAD50,RFC1,RUVBL1,RUVBL2,SGS1,SMC1A,TRIM29,UBAP2L,UBC,UBOX5,WDR61,XRN1,YLPM1,ZC3H11A
Quality control The peptide is characterized by mass spectroscopy
Key reference Harley,I., (2008) Gynecol. Oncol. 109 (3), 384-387
Description This is a synthetic peptide designed for use in combination with anti-MLH1 antibody (Catalog #: ARP56076_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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This product is for Research Use Only. Not for diagnostic, human, or veterinary use.
Optimal conditions of its use should be determined by end users.

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