SPAG8 Peptide - middle region (AAP55622)

Data Sheet
 
Sku AAP55622
Old sku AAPP34247
Price $99.00
Name SPAG8 Peptide - middle region (AAP55622)
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Size 100 ug
Gene SPAG8
Alias symbols BS-84, HSD-1, MGC26201, SMP1, SPAG3, hSMP-1
Gene id 26206
Description of target The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. SPAG8 is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa.The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.
Swissprot id Q99932-2
Protein accession num NP_758516
Nucleotide accession num NM_172312
Protein size 501 amino acids
Molecular weight 53kDa
Application WB
Partner proteins RAN,UBQLN4
Quality control The peptide is characterized by mass spectroscopy
Key reference Cheng,G.Y., (2007) Asian J. Androl. 9 (1), 23-29
Description This is a synthetic peptide designed for use in combination with anti-SPAG8 antibody (Catalog #: ARP55622_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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