| Sku |
AAP55585 |
| Old sku |
AAPP34146 |
| Price |
$99.00 |
| Name |
FBXW8 Peptide - middle region (AAP55585) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
FBXW8 |
| Alias symbols |
FBW6, FBW8, FBX29, FBXO29, MGC33534, FBXW6 |
| Gene id |
26259 |
| Description of target |
FBXW8 is a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW8 contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class.This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. |
| Swissprot id |
Q8N3Y1 |
| Protein accession num |
NP_699179 |
| Nucleotide accession num |
NM_153348 |
| Protein size |
598 amino acids |
| Molecular weight |
67kDa |
| Application |
WB |
| Partner proteins |
SKP1,CUL7,RBX1,SKP1,CUL7,RBX1,SKP1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Tsutsumi,T., (2008) Mol. Cell. Biol. 28 (2), 743-751 |
| Description |
This is a synthetic peptide designed for use in combination with anti-FBXW8 antibody (Catalog #: ARP55585_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
