| Sku |
AAP54309 |
| Old sku |
AAPP31058 |
| Price |
$99.00 |
| Name |
GUCA1A Peptide - N-terminal region (AAP54309) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
GUCA1A |
| Alias symbols |
COD3, GCAP, GCAP1, GUCA, GUCA1, CORD14, C6orf131, dJ139D8.6 |
| Gene id |
2978 |
| Description of target |
GUCA1A(GCAP1) plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. |
| Swissprot id |
P43080 |
| Protein accession num |
NP_000400 |
| Nucleotide accession num |
NM_000409 |
| Protein size |
201 amino acids |
| Molecular weight |
23kDa |
| Application |
WB |
| Partner proteins |
GUCY2D |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Michaelides,M., (2005) Ophthalmology 112 (8), 1442-1447 |
| Description |
This is a synthetic peptide designed for use in combination with anti-GUCA1A antibody (Catalog #: ARP54309_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
