| Sku |
AAP53840 |
| Old sku |
AAPP30679 |
| Price |
$99.00 |
| Name |
PIAS2 Peptide (AAP53840) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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|
| Size |
100 ug |
| Gene |
PIAS2 |
| Alias symbols |
MGC102682, MIZ1, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, miz, DIP, MIZ, ARIP3, PIASX |
| Gene id |
9063 |
| Description of target |
Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described. |
| Swissprot id |
O75928-2 |
| Protein accession num |
NP_775298 |
| Nucleotide accession num |
NM_173206 |
| Protein size |
572 amino acids |
| Molecular weight |
63kDa |
| Application |
WB |
| Partner proteins |
GTF2IRD1,HTNVsSgp1,SUMO1,UBE2I,ELK1,AR,BAT1,CHMP4B,ELK1,GRM8,GTF2I,GTF2IRD1,HDAC3,MBD1,MSX2,NAV2,PARK7,PIAS1,SMAD4,SNIP1,STAT4,SUMO1,UBE2I,AKT1,AKT1,AR,CDKN1A,CDKN1A,CDKN1C,CDKN2B,CDV3,DNMT3A,ESR1,ESR2,GTF2IRD1,ITGB5,MYC,NAV2,NR3C1,PARK7,PGR,SIAH1,SIAH2,STAT4,SUMO1,UBE2I,YWHAH |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Tsang,H.T., (2006) Genomics 88 (3), 333-346 |
| Description |
This is a synthetic peptide designed for use in combination with anti-PIAS2 antibody (Catalog #: ARP53840_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
