| Sku |
AAP53662 |
| Old sku |
AAPP30504 |
| Price |
$99.00 |
| Name |
ACTL7B Peptide - middle region (AAP53662) |
| Purchase info |
To purchase this peptide:
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|
| Size |
100 ug |
| Gene |
ACTL7B |
| Alias symbols |
Tact1 |
| Gene id |
10880 |
| Description of target |
ACTL7B is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known. |
| Swissprot id |
Q9Y614 |
| Protein accession num |
NP_006677 |
| Nucleotide accession num |
NM_006686 |
| Protein size |
416 amino acids |
| Molecular weight |
46kDa |
| Application |
WB |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Humphray,S.J., (2004) Nature 429 (6990), 369-374 |
| Description |
This is a synthetic peptide designed for use in combination with anti-ACTL7B antibody (Catalog #: ARP53662_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
