| Sku |
AAP52404 |
| Old sku |
AAPP14348 |
| Price |
$99.00 |
| Name |
CAPN10 Peptide - N-terminal region (AAP52404) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
CAPN10 |
| Alias symbols |
CANP10, NIDDM1 |
| Gene id |
11132 |
| Description of target |
CAPN10 is the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene. |
| Swissprot id |
Q9HC96 |
| Protein accession num |
NP_075573 |
| Nucleotide accession num |
NM_023085 |
| Protein size |
517 amino acids |
| Molecular weight |
58kDa |
| Application |
WB |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Kifagi,C., (2008) Diabetes Metab. 34 (3), 273-278 |
| Description |
This is a synthetic peptide designed for use in combination with anti-CAPN10 antibody (Catalog #: ARP52404_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
