PCDHGC4 Peptide (AAP49389)

Data Sheet
 
Sku AAP49389
Old sku AAPY02658
Price $99.00
Name PCDHGC4 Peptide (AAP49389)
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Size 100 ug
Gene PCDHGC4
Alias symbols MGC119489, PCDH-GAMMA-C4
Gene id 56098
Description of target PCDHGC4 is a single-pass type I membrane protein. It contains 6 cadherin domains.PCDHGC4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Swissprot id Q9Y5F7
Protein accession num NP_061751
Nucleotide accession num NM_018928
Protein size 938 amino acids
Molecular weight 98kDa
Application IHC, WB
Quality control The peptide is characterized by mass spectroscopy
Key reference Wu,Q., (2001) Genome Res. 11 (3), 389-404
Description This is a synthetic peptide designed for use in combination with anti-PCDHGC4 antibody (Catalog #: ARP49389_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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