| Sku |
AAP44289 |
| Old sku |
AAPP25668 |
| Price |
$99.00 |
| Name |
PSEN2 Peptide (AAP44289) |
| Purchase info |
To purchase this peptide:
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|
| Size |
100 ug |
| Gene |
PSEN2 |
| Alias symbols |
AD3L, AD4, PS2, STM2, CMD1V |
| Gene id |
5664 |
| Description of target |
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes.Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified. |
| Swissprot id |
P49810 |
| Protein accession num |
NP_000438 |
| Nucleotide accession num |
NM_000447 |
| Protein size |
448 amino acids |
| Molecular weight |
49kDa |
| Application |
IHC, WB |
| Partner proteins |
APH1A,APH1B,APP,BCL2L1,CAPN1,CASP1,CASP3,CASP6,CASP7,CASP8,CFLAR,CIB1,CSNK1A1,CSNK1D,CSNK2A1,CTNNB1,CTNND2,DOCK3,FHL2,FLNA,FLNB,ICAM5,KCNIP3,KCNIP4,METTL2A,NCSTN,NOTCH1,NOTCH2,NOTCH3,NOTCH4,PSENEN,RAB11A,SRI,UBQLN1,APBA1,APBA2,APBA3,APH1A,APP,BCL2L1,CAPN1,CIB1,FHL2,FLNB,GFAP,ICAM5,KCNIP3,KCNIP4,NCSTN,PSEN1,PSENEN,SRI,UBC,UBQLN1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
da (2005) Curr Alzheimer Res 2 (5), 507-514 |
| Description |
This is a synthetic peptide designed for use in combination with anti-PSEN2 antibody (Catalog #: ARP44289_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
