| Sku |
AAP43622 |
| Old sku |
AAPS15903 |
| Price |
$99.00 |
| Name |
ABCC8 Peptide - N-terminal region (AAP43622) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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|
| Size |
100 ug |
| Gene |
ABCC8 |
| Alias symbols |
ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, TNDM2, SUR1delta2 |
| Gene id |
6833 |
| Description of target |
ABCC8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCC8 is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion.The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
Q09428 |
| Protein accession num |
NP_000343 |
| Nucleotide accession num |
NM_000352 |
| Protein size |
1581 amino acids |
| Molecular weight |
177kDa |
| Application |
IHC, WB |
| Partner proteins |
CRYBB1,ENSA,KCNJ11,KCNJ8,KCNJ11,RAPGEF4 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Chiannilkulchai,N., (2008) J. Biol. Chem. 283 (14), 8778-8782 |
| Description |
This is a synthetic peptide designed for use in combination with anti-ABCC8 antibody (Catalog #: ARP43622_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
