| Sku |
AAP43283 |
| Old sku |
AAPP11358 |
| Price |
$99.00 |
| Name |
SH3RF1 Peptide - middle region (AAP43283) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
SH3RF1 |
| Alias symbols |
FLJ21602, KIAA1494, POSH, RNF142, SH3MD2 |
| Gene id |
57630 |
| Description of target |
SH3RF1 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). SH3RF1 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. |
| Swissprot id |
Q7Z6J0 |
| Protein accession num |
NP_065921 |
| Nucleotide accession num |
NM_020870 |
| Protein size |
888 amino acids |
| Molecular weight |
93kDa |
| Application |
WB |
| Partner proteins |
ADAM15,AKT2,MAP3K10,MAP3K11,MAP3K12,MAP3K9,PAK2,RACGAP1,SEMA6A,SIAH1,AKT2,MAP3K11 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Lyons,T.R., (2007) J. Biol. Chem. 282 (30), 21987-21997 |
| Description |
This is a synthetic peptide designed for use in combination with anti-SH3RF1 antibody (Catalog #: ARP43283_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
