FBXW2 Peptide - middle region (AAP43109)

Data Sheet
 
Sku AAP43109
Old sku AAPP25080
Price $99.00
Name FBXW2 Peptide - middle region (AAP43109)
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Size 100 ug
Gene FBXW2
Alias symbols FBW2, Fwd2, MGC117371, Md6
Gene id 26190
Description of target F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. FBXW2 is the second identified member of the F-box family and contains multiple WD-40 repeats.F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
Swissprot id Q9UKT8
Protein accession num NP_036296
Nucleotide accession num NM_012164
Protein size 454 amino acids
Molecular weight 51kDa
Application WB
Partner proteins SKP1,SKP1,SKP1,CUL1,SKP1,CDC34,CUL1,SKP1,UBE2D2
Quality control The peptide is characterized by mass spectroscopy
Key reference Yang,C.S., (2005) J. Biol. Chem. 280 (11), 10083-10090
Description This is a synthetic peptide designed for use in combination with anti-FBXW2 antibody (Catalog #: ARP43109_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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