Sku |
AAP43109 |
Old sku |
AAPP25080 |
Price |
$99.00 |
Name |
FBXW2 Peptide - middle region (AAP43109) |
Purchase info |
To purchase this peptide:
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|
Size |
100 ug |
Gene |
FBXW2 |
Alias symbols |
FBW2, Fwd2, MGC117371, Md6 |
Gene id |
26190 |
Description of target |
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. FBXW2 is the second identified member of the F-box family and contains multiple WD-40 repeats.F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. |
Swissprot id |
Q9UKT8 |
Protein accession num |
NP_036296 |
Nucleotide accession num |
NM_012164 |
Protein size |
454 amino acids |
Molecular weight |
51kDa |
Application |
WB |
Partner proteins |
SKP1,SKP1,SKP1,CUL1,SKP1,CDC34,CUL1,SKP1,UBE2D2 |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Yang,C.S., (2005) J. Biol. Chem. 280 (11), 10083-10090 |
Description |
This is a synthetic peptide designed for use in combination with anti-FBXW2 antibody (Catalog #: ARP43109_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
|
Tips |
See our General FAQ page. |
Availability |
In Stock |