Sku |
AAP42731 |
Old sku |
AAPP24956 |
Price |
$99.00 |
Name |
PLOD2 Peptide - middle region (AAP42731) |
Purchase info |
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|
Size |
100 ug |
Gene |
PLOD2 |
Alias symbols |
LH2, TLH |
Gene id |
5352 |
Description of target |
PLOD2 forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Swissprot id |
O00469-2 |
Protein accession num |
NP_891988 |
Nucleotide accession num |
NM_182943 |
Protein size |
758 amino acids |
Molecular weight |
84kDa |
Application |
IHC, WB |
Partner proteins |
PLOD2,HNRNPA1,PLOD2,RUVBL2 |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007) |
Description |
This is a synthetic peptide designed for use in combination with anti-PLOD2 antibody (Catalog #: ARP42731_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
|
Tips |
See our General FAQ page. |
Availability |
In Stock |