SNCA Peptide - middle region (AAP42350)

Data Sheet
 
Sku AAP42350
Old sku AAPP24705
Price $99.00
Name SNCA Peptide - middle region (AAP42350)
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Size 100 ug
Gene SNCA
Alias symbols MGC110988, NACP, PARK1, PARK4, PD1
Gene id 6622
Description of target Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease.Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced transcripts of SNCA have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined.
Swissprot id P37840-2
Protein accession num NP_009292
Nucleotide accession num NM_007308
Protein size 112 amino acids
Molecular weight 11kDa
Application WB
Partner proteins LAMP2,SNCAIP,ADRBK1,APP,BAD,BCL2L1,CALM1,COL25A1,COX3,CSNK1D,CSNK2A1,CSNK2A2,CYCS,ELK1,FGR,FYN,GRK5,GRK6,KLK6,LYN,MAP1B,MAPK1,MAPK8IP1,MAPT,PARK2,PLD1,PRKCE,PTK2B,SLC6A3,SNCAIP,SNCB,SQSTM1,SYK,TH,TOR1A,TUBA1A,UBB,YWHAB,YWHAE,YWHAH,ABZ2,ADRBK1,AIM46,ALB1,APE2,APP,ARL3,ARO1,ATG15,BAD,BAX,CALM1,CDC5,CKI1,COG6,CRH1,DPP1,EMC4,FUN26,FYN,GIP2,GLO4,GRK1,GRK5,GRK6,GTO1,GTT1,HBS1,HRD1,HSP30,INO4,MAD1,MAL31,MAP1B,MAPK1,MAPK3,MAPK8,MAPT,MEI4,MET17,MET32,MSB3,MTC2,MTC3,NAT3,NBP2,NIT2,NPP1,NUP53,OPI3,PARK2,PCA1,PDE2,PEX2,PHO13,PLD1,POX1,PSY3,PTK2,RNY1,RPL41A,SEC14,SEPT2,SEPT4,SLC6A3,SLC6A3,SNCAIP,SNCB,SOD2,SPF1,STF1,STP2,SUV3,SWR1,THI7,THR1,TLG2,TNA1,TOR1A,TSL1,UBC,UBC8,UBP3,VPS24,VPS28,VPS52,VPS60,WAR1,YAT1,YBR284W,YCK3,YCL042W,YCR050C,YCR051W,YDL118W,YFR035C,YGL262W,YGR130C,YGR201C,YJL118W,YKL100C,YKR023W,YPK9
Quality control The peptide is characterized by mass spectroscopy
Key reference Wu,K.P., (2008) J. Mol. Biol. 378 (5), 1104-1115
Description This is a synthetic peptide designed for use in combination with anti-SNCA antibody (Catalog #: ARP42350_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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Optimal conditions of its use should be determined by end users.

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