| Sku |
AAP42202 |
| Old sku |
AAPP24625 |
| Price |
$99.00 |
| Name |
ACTN4 Peptide (AAP42202) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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|
| Size |
100 ug |
| Gene |
ACTN4 |
| Alias symbols |
DKFZp686K23158, FSGS, FSGS1, ACTININ-4 |
| Gene id |
81 |
| Description of target |
Alpha actinins belong to the spectrin superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. ACTN4 is a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in its gene have been associated with focal and segmental glomerulosclerosis.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. |
| Swissprot id |
O43707 |
| Protein accession num |
NP_004915 |
| Nucleotide accession num |
NM_004924 |
| Protein size |
911 amino acids |
| Molecular weight |
100kDa |
| Application |
IHC, WB |
| Partner proteins |
CAMK2A,CAMK2B,LRRC7,PDLIM1,ACTC1,ACTN3,ADORA2A,ATP6V1B1,CAMK2A,CAMK2B,CAMK2G,COIL,COL17A1,GSN,ITGB1,LRRC7,MAGI1,MYOZ1,MYOZ2,NEB,NOS2,PDLIM1,PTPN11,PTPN6,SACS,SERPINE1,SLC2A4,SLC9A3R2,TJP1,TRIM3,USP6NL,CAMK2A,CAMK2B,COL17A1,GSN,INO80,Lrrc7,MAGI1,MYOZ1,MYOZ2,P2rx7,PDLIM1,SLC9A3R2,TRIM3,UBTF,USP6NL |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Kimura,K., (2006) Genome Res. 16 (1), 55-65 |
| Description |
This is a synthetic peptide designed for use in combination with anti-ACTN4 antibody (Catalog #: ARP42202_T100) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
