| Sku |
AAP42064 |
| Old sku |
AAPP24543 |
| Price |
$99.00 |
| Name |
MAP2K3 Peptide (AAP42064) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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|
| Size |
100 ug |
| Gene |
MAP2K3 |
| Alias symbols |
MAPKK3, MEK3, MKK3, PRKMK3, SAPKK2, SAPKK-2 |
| Gene id |
5606 |
| Description of target |
MAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. |
| Swissprot id |
P46734-2 |
| Protein accession num |
NP_002747 |
| Nucleotide accession num |
NM_002756 |
| Protein size |
318 amino acids |
| Molecular weight |
36kDa |
| Application |
IHC, WB |
| Partner proteins |
MAPK14,MAP3K4,DCTN1,DYRK1B,ELK1,MAP3K4,MAPK12,MAPK14,MAPK3,MAPK8IP2,PLCB2,SMAD7,TAOK1,TAOK2,MAP2K6,MAP3K4,MAPK14,MAPK3,MAPK8IP2,Mapk14,NPHS1,PLCB2,SMAD7,TAOK2 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Prickett,T.D. (2007) Mol. Cell. Biol. 27 (12), 4217-4227 |
| Description |
This is a synthetic peptide designed for use in combination with anti-MAP2K3 antibody (Catalog #: ARP42064_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
