| Sku |
AAP41462 |
| Old sku |
AAPS09208 |
| Price |
$99.00 |
| Name |
ACTN2 Peptide (AAP41462) |
| Purchase info |
To purchase this peptide:
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|
| Size |
100 ug |
| Gene |
ACTN2 |
| Alias symbols |
CMD1AA |
| Gene id |
88 |
| Description of target |
The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibres, while ACTN3 expression is restricted to a subset of type 2 fibres. Murine Actn2 and Actn3 are differentially expressed, spatially and temporally, during embryonic development and, in contrast to humans, alpha-actinin-2 expression does not completely overlap alpha-actinin-3 in postnatal skeletal muscle, suggesting independent function.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-39 DC378038.1 17-55 40-2961 BC051770.1 1-2922 2962-3458 CB153006.1 65-561 3459-3637 AL359185.25 28531-28709 3638-4210 M86406.1 3609-4181 4211-4528 AL359185.25 29283-29600 |
| Swissprot id |
P35609 |
| Protein accession num |
NP_001094 |
| Nucleotide accession num |
NM_001103 |
| Protein size |
894 amino acids |
| Molecular weight |
104kDa |
| Application |
IHC, WB |
| Partner proteins |
ANG,CAPN1,DISC1,GRIN1,LDB3,MYOZ1,ACTN2,ACTN3,ADAM12,ADORA2A,ANG,ATXN2,CAMK2A,CAMK2D,CAMK2G,CAPN1,COIL,DISC1,DLG1,DLG4,EPS8L1,GRIN1,GRIN2B,KAT2B,KCNA4,KCNA5,LDB3,LRP12,LRRC7,MED14,MYOZ1,MYOZ2,MYOZ3,MYPN,NCOA2,NCOR1,NR1I2,NRIP1,PALLD,PDLIM1,PKD2,RAVER1,SELE,SNW1,SSX2IP,TTN,UTRN,ACTN3,ADAM12,DISC1,DLG1,DLG4,GRIN2B,KCNA5,LDB3,MYOZ1,MYPN,PDLIM1,ST7,TNN,Tuba1a |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Bos,J.M., (2008) Am. Heart J. 155 (6), 1128-1134 |
| Description |
This is a synthetic peptide designed for use in combination with anti-ACTN2 antibody (Catalog #: ARP41462_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
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| Tips |
See our General FAQ page. |
| Availability |
In Stock |
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