Sku |
AAP40716 |
Old sku |
AAPP10454 |
Price |
$99.00 |
Name |
NONO Peptide (AAP40716) |
Purchase info |
To purchase this peptide:
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|
Size |
100 ug |
Gene |
NONO |
Alias symbols |
P54, NMT55, NRB54, P54NRB |
Gene id |
4841 |
Description of target |
NONO is DNA- and RNA binding protein, involved in several nuclear processes. It binds the conventional octamer sequence in double stranded DNA. It also binds single-stranded DNA and RNA at a site independent of the duplex site. It is involved in pre-mRNA splicing and interacts with U5 snRNA. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs, be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 and be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. |
Swissprot id |
Q15233 |
Protein accession num |
NP_031389 |
Nucleotide accession num |
NM_007363 |
Protein size |
471 amino acids |
Molecular weight |
52kDa |
Application |
IF, IHC, WB |
Partner proteins |
PCNA,SFPQ,AR,CA2,FXR2,MAD1L1,NONO,PIN1,PLEKHF2,POLR2A,PSPC1,SFPQ,SPI1,ZNRD1,AR,CA2,FXR2,MAD1L1,NONO,PIN1,PLEKHF2,PMS1,PSPC1,Polr2a,SFPQ,SOCS3,SPI1,ZNRD1 |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Kimura,K., (2006) Genome Res. 16 (1), 55-65 |
Description |
This is a synthetic peptide designed for use in combination with anti-NONO antibody (Catalog #: ARP40716_T100) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
|
Tips |
See our General FAQ page. |
Availability |
In Stock |