ACO1 Peptide (AAP40390)

Data Sheet
 
Sku AAP40390
Old sku AAPP22134
Price $99.00
Name ACO1 Peptide (AAP40390)
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Size 100 ug
Gene ACO1
Alias symbols IRP1, ACONS, IREB1, IREBP, IREBP1
Gene id 48
Description of target ACO1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Swissprot id P28271
Protein accession num NP_002188
Nucleotide accession num NM_002197
Protein size 889 amino acids
Molecular weight 98kDa
Application IHC, WB
Quality control The peptide is characterized by mass spectroscopy
Key reference Clarke,S.L., (2006) EMBO J. 25 (3), 544-553
Description This is a synthetic peptide designed for use in combination with anti-ACO1 antibody (Catalog #: ARP40390_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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