Sku |
AAP40390 |
Old sku |
AAPP22134 |
Price |
$99.00 |
Name |
ACO1 Peptide (AAP40390) |
Purchase info |
To purchase this peptide:
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|
Size |
100 ug |
Gene |
ACO1 |
Alias symbols |
IRP1, ACONS, IREB1, IREBP, IREBP1 |
Gene id |
48 |
Description of target |
ACO1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. |
Swissprot id |
P28271 |
Protein accession num |
NP_002188 |
Nucleotide accession num |
NM_002197 |
Protein size |
889 amino acids |
Molecular weight |
98kDa |
Application |
IHC, WB |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Clarke,S.L., (2006) EMBO J. 25 (3), 544-553 |
Description |
This is a synthetic peptide designed for use in combination with anti-ACO1 antibody (Catalog #: ARP40390_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
|
Tips |
See our General FAQ page. |
Availability |
In Stock |