| Sku |
AAP38820 |
| Old sku |
AAPP21028 |
| Price |
$99.00 |
| Name |
CTCF Peptide (AAP38820) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
CTCF |
| Gene id |
10664 |
| Description of target |
CTCF is a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in CTCF have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. |
| Swissprot id |
P49711 |
| Protein accession num |
NP_006556 |
| Nucleotide accession num |
NM_006565 |
| Protein size |
727 amino acids |
| Molecular weight |
83kDa |
| Application |
CHIP, WB |
| Partner proteins |
EIF2S3,THRB,YBX1,HMGB1,POLR2A,SMAD3,SMAD4,THRB,YBX1,CHD7,CHD8,SUZ12,YBX1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Defossez,P.A., (2005) J. Biol. Chem. 280 (52), 43017-43023 |
| Description |
This is a synthetic peptide designed for use in combination with anti-CTCF antibody (Catalog #: ARP38820_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
