Sku |
AAP38653 |
Old sku |
AAPP20843 |
Price |
$99.00 |
Name |
TAF6 Peptide - C-terminal region (AAP38653) |
Purchase info |
To purchase this peptide:
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|
Size |
100 ug |
Gene |
TAF6 |
Alias symbols |
DKFZp781E21155, MGC:8964, TAF2E, TAFII70, TAFII80, TAFII85, TAFII-70, TAFII-80, TAF(II)70, TAF(II)80 |
Gene id |
6878 |
Description of target |
TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF6 is one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1,the largest subunit of TFIID. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis. |
Swissprot id |
P49848 |
Protein accession num |
NP_005632 |
Nucleotide accession num |
NM_005641 |
Protein size |
677 amino acids |
Molecular weight |
73kDa |
Application |
WB, CHIP |
Partner proteins |
TAF9,CIITA,GTF2E1,RELA,SH3KBP1,TAF1,TAF10,TAF11,TAF12,TAF2,TAF4,TAF5,TAF6,TAF7,TAF8,TAF9,AHR,GTF2A1,GTF2E1,RELA,SH3KBP1,TAF1,TAF12,TAF13,TAF5,TAF9,TBP,TBPL1,TP53 |
Subunit |
6 |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Beausoleil,S.A., (2006) Nat. Biotechnol. 24 (10), 1285-1292 |
Description |
This is a synthetic peptide designed for use in combination with anti-TAF6 antibody (Catalog #: ARP38653_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
|
Tips |
See our General FAQ page. |
Availability |
In Stock |