E2F2 Peptide - middle region (AAP38418)

Data Sheet
 
Sku AAP38418
Old sku AAPP20608
Price $99.00
Name E2F2 Peptide - middle region (AAP38418)
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Size 100 ug
Gene E2F2
Alias symbols E2F-2
Gene id 1870
Description of target E2F2 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot id Q14209
Protein accession num NP_004082
Nucleotide accession num NM_004091
Protein size 437 amino acids
Molecular weight 47kDa
Application IHC, WB
Partner proteins E2F4,RBL2,CDC25A,CDC6,E2F1,EAPP,FHL2,GAB2,JMY,MT1G,MYBL2,PPP1R13B,RB1,RB1,RB1,RBL1,RYBP,SETD8,TP53BP2,TP53INP1,UXT,ARID3A,BCAR1,BRD2,CDK3,RB1,RYBP,SETD8,SP1,TFDP1,TFDP2,YY1,BCAR1,BRD2,FHL2,RB1,RNF144A,RYBP,SETD8,SPIB,Sp1
Quality control The peptide is characterized by mass spectroscopy
Key reference Raj,D., (2008) Carcinogenesis 29 (1), 194-201
Description This is a synthetic peptide designed for use in combination with anti-E2F2 antibody (Catalog #: ARP38418_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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