Sku |
AAP38418 |
Old sku |
AAPP20608 |
Price |
$99.00 |
Name |
E2F2 Peptide - middle region (AAP38418) |
Purchase info |
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|
Size |
100 ug |
Gene |
E2F2 |
Alias symbols |
E2F-2 |
Gene id |
1870 |
Description of target |
E2F2 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
Swissprot id |
Q14209 |
Protein accession num |
NP_004082 |
Nucleotide accession num |
NM_004091 |
Protein size |
437 amino acids |
Molecular weight |
47kDa |
Application |
IHC, WB |
Partner proteins |
E2F4,RBL2,CDC25A,CDC6,E2F1,EAPP,FHL2,GAB2,JMY,MT1G,MYBL2,PPP1R13B,RB1,RB1,RB1,RBL1,RYBP,SETD8,TP53BP2,TP53INP1,UXT,ARID3A,BCAR1,BRD2,CDK3,RB1,RYBP,SETD8,SP1,TFDP1,TFDP2,YY1,BCAR1,BRD2,FHL2,RB1,RNF144A,RYBP,SETD8,SPIB,Sp1 |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Raj,D., (2008) Carcinogenesis 29 (1), 194-201 |
Description |
This is a synthetic peptide designed for use in combination with anti-E2F2 antibody (Catalog #: ARP38418_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
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Tips |
See our General FAQ page. |
Availability |
In Stock |