| Sku |
AAP38136 |
| Old sku |
AAPP20312 |
| Price |
$99.00 |
| Name |
JUNB Peptide (AAP38136) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
JUNB |
| Alias symbols |
AP-1 |
| Gene id |
3726 |
| Description of target |
The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Jun B and Jun D, have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. JunB is involved in many types of human carcinoma including T-cell lymphomas, CML,primary cutaneous lymphomas. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.JunB is an important regulator of erythroid Differentiation. |
| Swissprot id |
P17275 |
| Protein accession num |
NP_002220 |
| Nucleotide accession num |
NM_002229 |
| Protein size |
347 amino acids |
| Molecular weight |
36kDa |
| Application |
WB |
| Partner proteins |
BRCA1,ESR1,JUN,BATF,BCL6,BRCA1,ESR1,FOS,FOSB,FOSL1,FOSL2,JDP2,JUNB,MAPK14,MAPK8,NFE2L1,NINL,SMAD3,SMAD4,BATF,BCL6,BRCA1,FOSL1,MAPK8,MAPK9,NINL,SMAD3,SMAD4,SMARCA4,Smarcd1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Troen,G., (2004) J Mol Diagn 6 (4), 297-307 |
| Description |
This is a synthetic peptide designed for use in combination with anti-JUNB antibody (Catalog #: ARP38136_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
