| Sku |
AAP37988 |
| Old sku |
AAPP20090 |
| Price |
$99.00 |
| Name |
WT1 Peptide - N-terminal region (AAP37988) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
WT1 |
| Alias symbols |
AWT1, GUD, WAGR, WIT-2, WT33, NPHS4, EWS-WT1 |
| Gene id |
7490 |
| Description of target |
WT1 is a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms.This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. |
| Swissprot id |
E9PMK7 |
| Protein accession num |
NP_000369 |
| Nucleotide accession num |
NM_000378 |
| Protein size |
514 amino acids |
| Molecular weight |
56kDa |
| Application |
WB |
| Partner proteins |
AREG,CIAO1,CREBBP,FHL2,PAWR,PAX2,PRKACA,TP53,TP63,TP73,U2AF2,UBE2I,WTAP,WTIP,PAWR,Pawr,TP53,U2AF2,UBE2I,WTAP |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Ruteshouser,E.C., (2008) Genes Chromosomes Cancer 47 (6), 461-470 |
| Description |
This is a synthetic peptide designed for use in combination with anti-WT1 antibody (Catalog #: ARP37988_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
