| Sku |
AAP35439 |
| Old sku |
AAPP06677 |
| Price |
$99.00 |
| Name |
KCNN2 Peptide - middle region (AAP35439) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
KCNN2 |
| Alias symbols |
KCa2.2, SK2, SKCA2, hSK2 |
| Gene id |
3781 |
| Description of target |
KCNN2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This protein is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for KCNN2.Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN2 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP.Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene. |
| Swissprot id |
Q6PJI0 |
| Protein accession num |
NP_740721 |
| Nucleotide accession num |
NM_170775 |
| Protein size |
231 amino acids |
| Molecular weight |
26kDa |
| Application |
IHC, WB |
| Partner proteins |
CALM1,KCNN2,CALM1,KCNN2 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Morimoto,T., (2007) J. Pharmacol. Sci. 104 (1), 94-98 |
| Description |
This is a synthetic peptide designed for use in combination with anti-KCNN2 antibody (Catalog #: ARP35439_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
