| Sku |
AAP35330 |
| Old sku |
AAPP06566 |
| Price |
$99.00 |
| Name |
TRPV4 Peptide - middle region (AAP35330) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
TRPV4 |
| Alias symbols |
OTRPC4, TRP12, VR-OAC, VRL-2, VRL2, VROAC, CMT2C, SPSMA, HMSN2C, SSQTL1 |
| Gene id |
59341 |
| Description of target |
TRPV4 is a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation of TRPV4 by exposure to hypotonicity within the physiological range exhibits an outward rectification. TRPV4 also activated by low pH, citrate and phorbol esters and increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3) This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Two transcript variants encoding different isoforms have been found for this gene. |
| Swissprot id |
Q9HBA0-2 |
| Protein accession num |
NP_671737 |
| Nucleotide accession num |
NM_147204 |
| Protein size |
811 amino acids |
| Molecular weight |
91kDa |
| Application |
IHC, WB |
| Partner proteins |
CALM1,FYN,HCK,ITCH,LCK,LYN,MAP7,PACSIN1,PACSIN2,PACSIN3,SRC,TRPV4,YES1,FYN,HCK,LCK,LYN,MAP7,OS9,PACS1,SRC,UBC,YES1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Corey,D.P. (er) Pflugers Arch. (2008) In press |
| Description |
This is a synthetic peptide designed for use in combination with anti-TRPV4 antibody (Catalog #: ARP35330_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
