| Sku |
AAP34923 |
| Old sku |
AAPP06147 |
| Price |
$99.00 |
| Name |
KCNA1 Peptide - middle region (AAP34923) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
KCNA1 |
| Alias symbols |
AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MGC126782, MGC138385, MK1, RBK1 |
| Gene id |
3736 |
| Description of target |
KCNA1 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). Sequence Note: This RefSeq record was created largely from genomic sequence because transcripts were not available for the entire length of the gene. This transcript is supported by sequences from mouse. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
Q09470 |
| Protein accession num |
NP_000208 |
| Nucleotide accession num |
NM_000217 |
| Protein size |
495 amino acids |
| Molecular weight |
56kDa |
| Application |
WB |
| Partner proteins |
DLG1,DLG4,KCNE4,CNTNAP1,DLG4,KCNA2,KCNA3,KCNA4,RTN4 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Tan,K.M., (2008) Neurology 70 (20), 1883-1890 |
| Description |
This is a synthetic peptide designed for use in combination with anti-KCNA1 antibody (Catalog #: ARP34923_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
