| Sku |
AAP34797 |
| Old sku |
AAPP05991 |
| Price |
$99.00 |
| Name |
MBD4 Peptide - middle region (AAP34797) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
MBD4 |
| Alias symbols |
MED1 |
| Gene id |
8930 |
| Description of target |
MBD4 is involved with DNA methylation. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD3 comprise a family of nuclear proteins related by??he presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
O95243 |
| Protein accession num |
NP_003916 |
| Nucleotide accession num |
NM_003925 |
| Protein size |
580 amino acids |
| Molecular weight |
66kDa |
| Application |
WB, CHIP |
| Partner proteins |
MLH1,CSNK2B,FADD,MLH1,CSNK2B,DNMT3B,FADD,HDAC1,MLH1,SIN3A,TRIM27,Trim27 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Miao,R., (er) Lung Cancer (2008) In press |
| Description |
This is a synthetic peptide designed for use in combination with anti-MBD4 antibody (Catalog #: ARP34797_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
