CLDN16 Peptide (AAP33632)

Data Sheet
 
Sku AAP33632
Old sku AAPP04688
Price $99.00
Name CLDN16 Peptide (AAP33632)
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Size 100 ug
Gene CLDN16
Alias symbols HOMG3, PCLN1
Gene id 10686
Description of target Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure.
Swissprot id Q9Y5I7
Protein accession num NP_006571
Nucleotide accession num NM_006580
Protein size 305 amino acids
Molecular weight 34kDa
Application WB
Partner proteins TJP1
Quality control The peptide is characterized by mass spectroscopy
Key reference Muller,D., et al., (2003) Am. J. Hum. Genet. 73 (6), 1293-1301
Description This is a synthetic peptide designed for use in combination with anti-CLDN16 antibody (Catalog #: ARP33632_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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