| Sku |
AAP33394 |
| Old sku |
AAPP04440 |
| Price |
$99.00 |
| Name |
TAF4 Peptide - middle region (AAP33394) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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|
| Size |
100 ug |
| Gene |
TAF4 |
| Alias symbols |
FLJ41943, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135 |
| Gene id |
6874 |
| Description of target |
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF4 is one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases.Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
O00268 |
| Protein accession num |
NP_003176 |
| Nucleotide accession num |
NM_003185 |
| Protein size |
1085 amino acids |
| Molecular weight |
110kDa |
| Application |
WB, CHIP
|
| Partner proteins |
AHR,ATF7,HTT,AHR,ATF7,CBX3,CBX5,CREM,GTF2A1,GTF2A2,HTT,SP1,TAF1,TAF10,TAF11,TAF12,TAF2,TAF5,TAF6,TAF7,TAF8,TAF9,CBX5,CREM,GTF2A1,GTF2A2,KAT2A,SAP130,SP1,SUPT3H,TAF1,TAF10,TAF12,TAF13,TAF4,TAF5,TAF8,TAF9,TBP,TBPL1 |
| Subunit |
4 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Liu,W.L., (2008) Mol. Cell 29 (1), 81-91 |
| Description |
This is a synthetic peptide designed for use in combination with anti-TAF4 antibody (Catalog #: ARP33394_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
