| Sku |
AAP32723 |
| Old sku |
AAPP03737 |
| Price |
$99.00 |
| Name |
NOTCH2 Peptide - middle region (AAP32723) |
| Purchase info |
To purchase this peptide:
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|
| Size |
100 ug |
| Gene |
NOTCH2 |
| Alias symbols |
AGS2, hN2, HJCYS |
| Gene id |
4853 |
| Description of target |
NOTCH2 is a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. NOTCH2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH2 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
Q04721 |
| Protein accession num |
NP_077719 |
| Nucleotide accession num |
NM_024408 |
| Protein size |
2471 amino acids |
| Molecular weight |
85kDa |
| Application |
WB |
| Partner proteins |
tat,CNTN1,DLL1,DTX1,GSK3B,JAG1,JAG2,LFNG,MAML1,MAML2,MAML3,MFNG,MYOC,PSEN1,PSEN2,RBPJ,SMAD1,CNTN1,DLL1,GSK3B,JAG1,JAG2,MAML1,RBPJ |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Troen,G., (er) Haematologica (2008) In press |
| Description |
This is a synthetic peptide designed for use in combination with anti-NOTCH2 antibody (Catalog #: ARP32723_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
