Sku |
AAP32665 |
Old sku |
AAPP03675 |
Price |
$99.00 |
Name |
IKBKB Peptide - N-terminal region (AAP32665) |
Purchase info |
To purchase this peptide:
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|
Size |
100 ug |
Gene |
IKBKB |
Alias symbols |
FLJ40509, IKK-beta, IKK2, IKKB, MGC131801, NFKBIKB |
Gene id |
3551 |
Description of target |
NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-203 AL708460.1 9-211 204-3077 AF080158.1 170-3043 3078-3916 AK023193.1 1980-2818 |
Swissprot id |
O14920 |
Protein accession num |
NP_001547 |
Nucleotide accession num |
NM_001556 |
Protein size |
756 amino acids |
Molecular weight |
86kDa |
Application |
WB |
Partner proteins |
BIRC3,CDC37,CHUK,CHUK,FOXO3,IKBKAP,IKBKB,IKBKG,IL8,MAP3K14,NFKBIA,NFKBIA,NFKBIA,NFKBIB,PRKCQ,ACVR1,AKT1,CASP8,CDC37,CFLAR,CHUK,CSF2RA,CTNNB1,EIF2AK2,EIF2AK3,FANCA,FOXO3,HSP90AA1,HSP90AB1,IKBKAP,IKBKB,IKBKG,IRS1,KIAA1967,MAP3K11,MAP3K13,MAP3K14,MAP3K3,MAP3K7,NCOA3,NFKB1,NFKB2,NFKBIA,NFKBIB,NR2C2,PEBP1,PPM1B,PRKCB,PRKCQ,PRKCZ,RELA,SRC,STAP2,TANK,TBK1,TGFBR1,TNFAIP3,TNFRSF1A,TRAF2,TRAF3IP2,TRPC4AP,UBB,YWHAB,BTRC,CASP8,CDC37,CHUK,CNTN2,CTNNB1,EIF2AK2,FANCA,IKBKAP,IKBKB,IKBKG,IRAK1,IRS1,MAP3K1,MAP3K11,MAP3K13,MAP3K14,MAP3K7,NCOA3,NFKB1,NFKBIA,NFKBIB,PPM1B,PRDX3,PRKCQ,PRKDC,Pebp1,TNFAIP3,TNFRSF1A,TRAF2,TRAF3IP2,TRPC4AP |
Subunit |
beta |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Hu,W., (2008) Biochem. J. 412 (1), 35-43 |
Description |
This is a synthetic peptide designed for use in combination with anti-IKBKB antibody (Catalog #: ARP32665_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
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Tips |
See our General FAQ page. |
Availability |
In Stock |
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