TAF1 Peptide - middle region (AAP32472)

Data Sheet
 
Sku AAP32472
Old sku AAPP03470
Price $99.00
Name TAF1 Peptide - middle region (AAP32472)
Purchase info To purchase this peptide:
  • Copy peptide sku
  • Click on this link
  • Paste into field "Peptide Sku"
Size 100 ug
Gene TAF1
Alias symbols BA2R, CCG1, CCGS, DYT3, KAT4, NSCL2, OF, P250, TAF2A, TAFII250, XDP, N-TAF1, DYT3/TAF1
Gene id 6872
Description of target Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF1 encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Two transcripts encoding different isoforms have been identified for this gene.
Swissprot id P21675-2
Protein accession num NP_004597
Nucleotide accession num NM_004606
Protein size 1893 amino acids
Molecular weight 215kDa
Application WB, CHIP
Partner proteins ASF1A,CCND1,RB1,ASF1A,ASF1B,BRMS1,CCNA2,CCND1,EDF1,EWSR1,FOS,GFI1B,GTF2A1,GTF2F1,HIST3H3,HMGB1,HSF1,JUN,MDM2,MSX1,RB1,RBL1,RBL2,RELA,SUB1,TAF1,TAF10,TAF11,TAF12,TAF15,TAF2,TAF4,TAF5,TAF6,TAF7,TAF8,TAF9,TBP,UBTF,BAX,CCND1,CSNK2A1,FOS,GTF2A1,GTF2E1,GTF2F1,JUN,MDM2,PAX6,RB1,RBL1,RBL2,RELA,TAF10,TAF13,TAF2,TAF4,TAF4B,TAF5,TAF6,TAF7,TAF7L,TAF9,TBP,TBPL1,TP53,UBTF
Subunit 1
Quality control The peptide is characterized by mass spectroscopy
Key reference Herzfeld,T., (2007) Mamm. Genome 18 (11), 787-795
Description This is a synthetic peptide designed for use in combination with anti-TAF1 antibody (Catalog #: ARP32472_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
Protocol
Tips

See our General FAQ page.

Availability In Stock
 

AVIVA SYSTEMS BIOLOGY manufactures and sells quality antibody products covering genome wide proteins.

AVIVA SYSTEMS BIOLOGY
10211 Pacific Mesa Blvd, Ste 401, San Diego, CA 92121 USA | Tel: (858)552-6979 | info@avivasysbio.com