| Sku |
AAP32253 |
| Old sku |
AAPP03234 |
| Price |
$99.00 |
| Name |
EPAS1 Peptide - middle region (AAP32253) |
| Purchase info |
To purchase this peptide:
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|
| Size |
100 ug |
| Gene |
EPAS1 |
| Alias symbols |
HIF2A, HLF, MOP2, PASD2, ECYT4, bHLHe73 |
| Gene id |
2034 |
| Description of target |
EPAS1 is a transcription factor involved in the induction of oxygen regulated genes. EPAS1 binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. EPAS1 regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. EPAS1 may also play a role in the formation of the endothelium that gives rise to the blood brain barrier. EPAS1 is a potent activator of the Tie-2 tyrosine kinase expression. The activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction of EPAS1 with redox regulatory protein APEX seems to activate CTAD. |
| Swissprot id |
Q99814 |
| Protein accession num |
NP_001421 |
| Nucleotide accession num |
NM_001430 |
| Protein size |
870 amino acids |
| Molecular weight |
90kDa |
| Application |
WB |
| Partner proteins |
ARNT,ARNT,VHL,ARNT,ARNTL,ARNTL2,EGLN1,EGLN2,EGLN3,EIF3E,EP300,MAX,PRKD1,SMAD3,VHL,ARNT,ARNTL,PSMC3,Ruvbl1,VHL |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Koizume,S., (2008) Biochem. Biophys. Res. Commun. 371 (2), 251-255 |
| Description |
This is a synthetic peptide designed for use in combination with anti-EPAS1 antibody (Catalog #: ARP32253_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
