COPS5 Peptide - N-terminal region (AAP31512)

Data Sheet
 
Sku AAP31512
Old sku AAPP02274
Price $99.00
Name COPS5 Peptide - N-terminal region (AAP31512)
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Size 100 ug
Gene COPS5
Alias symbols CSN5, JAB1, MGC3149, MOV-34, SGN5
Gene id 10987
Description of target COPS5 is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot id Q92905
Protein accession num NP_006828
Nucleotide accession num NM_006837
Protein size 334 amino acids
Molecular weight 37kDa
Application WB
Partner proteins HIF1A,CDKN1B,COPS6,S100A7,BCL3,CDKN1B,COPS2,COPS3,COPS4,COPS6,COPS7A,COPS8,CUL5,ERN1,ESR1,F2RL1,GFER,GFI1B,GPS1,HAND2,HIF1A,HNF4A,HNF4G,JUN,JUND,MIF,NCOA1,NR4A2,NR4A3,PPARG,RNF139,RORA,S100A7,SMAD2,SMAD4,TP53,TXN,UCHL1,BCL3,BTBD2,CDKN1B,COPS2,COPS3,COPS4,COPS6,COPS7A,COPS7B,COPS8,CPSF1,CUL1,CUL2,CUL3,CUL4A,CUL4B,DCAF11,DCAF4,DDB1,DDB2,ERCC8,FBXO11,FBXO17,FBXO22,GFER,GPS1,HAND2,JUN,JUND,KLHL13,KLHL15,KLHL18,KLHL22,KLHL24,KLHL9,LRRC14,MAPRE1,MDM2,MIF,NEDD8,PPIL5,PTGS2,S100A7,SAP130,SKP2,SMAD4,TOR1AIP2,TP53,TRAF2,UCHL1,UCHL3,VPRBP
Subunit 5
Quality control The peptide is characterized by mass spectroscopy
Key reference Zhang,X.C., (2008) J. Cell. Biochem. 103 (4), 1219-1230
Description This is a synthetic peptide designed for use in combination with anti-COPS5 antibody (Catalog #: ARP31512_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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