TBP Peptide (AAP31331)

Data Sheet
 
Sku AAP31331
Old sku AAPP02082
Price $99.00
Name TBP Peptide (AAP31331)
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Size 100 ug
Gene TBP
Alias symbols HDL4, GTF2D, SCA17, TFIID, GTF2D1
Gene id 6908
Description of target Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.
Swissprot id P20226
Protein accession num NP_003185
Nucleotide accession num NM_003194
Protein size 339 amino acids
Molecular weight 38kDa
Application WB
Partner proteins AHR,BAX,EP300,GLI2,HTT,IRF1,MYC,POU3F2,RB1,RIBIN,TAF1A,TAF1B,TAF1C,TAF2,ABT1,AHR,BCL3,BRF1,BRF2,BTAF1,CAND2,CREG1,CREM,CXXC1,DHX9,DR1,DRAP1,EDF1,EMID2,ESR1,FATE1,FOS,FOXF2,GTF2A1,GTF2A2,GTF2B,GTF2E1,GTF2E2,GTF2F2,GTF3C3,HAP1,HMGB1,HNRNPK,HSF1,HTT,IKZF1,JUN,JUND,KDM5A,MCM2,MDM2,MSX1,MYC,NACA,NCOA1,NCOA3,NFYB,NR3C1,PAX5,PAX6,PIAS1,PIAS3,POU2F1,POU2F2,POU3F2,PSMC2,RB1,REL,RELA,RNF4,RUVBL1,RXRA,SNAPC1,SNAPC2,SNAPC4,SP1,SPI1,SPIB,SUB1,TAF1,TAF10,TAF11,TAF12,TAF13,TAF1A,TAF1B,TAF1C,TAF1L,TAF5,TAF7L,TBP,TEAD1,TP53,TRAM2,TRIP4,UBTF,WDR62,ZNF76,AHR,AR,ATF4,BCL3,BRF1,BRF2,BTAF1,CBX5,CD3EAP,CITED2,CREG1,CREM,CTBP1,DHX9,DRAP1,EDF1,ESR1,FOS,FOXF2,GTF2A1,GTF2A1L,GTF2A2,GTF2B,GTF2E1,GTF2E2,GTF2F1,GTF2F2,GTF2H4,GTF3C2,GTF3C3,GTF3C4,GTF3C5,HMGB1,HSF1,IKZF1,JUN,KDM5A,KLF5,MCM2,MDM2,MSX1,MYC,NCOA1,NCOA6,NFYB,NFYC,NR3C1,PAX3,PAX6,POLR2A,POLR3C,POLR3F,POU2F1,POU2F2,PSMC2,RB1,REL,RELA,RNF4,RRN3,RUVBL1,RXRA,SNAPC2,SNAPC4,SNURF,SPIB,TAF1,TAF10,TAF11,TAF13,TAF15,TAF1A,TAF1B,TAF1C,TAF1D,TAF1L,TAF2,TAF4,TAF5,TAF6,TAF7,TAF7L,TAF9,TBP,TBPL1,TCEA1,TP53,UBTF,WDR62
Quality control The peptide is characterized by mass spectroscopy
Key reference Reid,S.J., et al., (2004) Brain Res. Mol. Brain Res. 125 (1-2), 120-128
Description This is a synthetic peptide designed for use in combination with anti-TBP antibody (Catalog #: P100971_T100) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
Protocol
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Optimal conditions of its use should be determined by end users.

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