JUNB Peptide (AAP31301)

Data Sheet
 
Sku AAP31301
Old sku AAPP02050
Price $99.00
Name JUNB Peptide (AAP31301)
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Size 100 ug
Gene JUNB
Alias symbols AP-1
Gene id 3726
Description of target The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Jun B and Jun D, have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. JunB is involved in many types of human carcinoma including T-cell lymphomas, CML,primary cutaneous lymphomas. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.JunB is an important regulator of erythroid Differentiation.
Swissprot id P17275
Protein accession num NP_002220
Nucleotide accession num NM_002229
Protein size 347 amino acids
Molecular weight 36kDa
Application WB
Partner proteins BRCA1,ESR1,JUN,BATF,BCL6,BRCA1,ESR1,FOS,FOSB,FOSL1,FOSL2,JDP2,JUNB,MAPK14,MAPK8,NFE2L1,NINL,SMAD3,SMAD4,BATF,BCL6,BRCA1,FOSL1,MAPK8,MAPK9,NINL,SMAD3,SMAD4,SMARCA4,Smarcd1
Quality control The peptide is characterized by mass spectroscopy
Key reference Troen,G., (2004) J Mol Diagn 6 (4), 297-307
Description This is a synthetic peptide designed for use in combination with anti-JUNB antibody (Catalog #: P100946_T100) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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