NFKBIA Peptide (AAP31294)

Data Sheet
 
Sku AAP31294
Old sku AAPP02043
Price $99.00
Name NFKBIA Peptide (AAP31294)
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Size 100 ug
Gene NFKBIA
Alias symbols IKBA, MAD-3, NFKBI
Gene id 4792
Description of target NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
Swissprot id P25963
Protein accession num NP_065390
Nucleotide accession num NM_020529
Protein size 317 amino acids
Molecular weight 36kDa
Application IHC, WB
Partner proteins ARRB1,ARRB2,BTRC,CHUK,CHUK,COMMD1,DYNLL1,ERC1,HDAC1,HDAC3,IKBKB,IKBKB,IKBKB,LCK,NFKB1,RELA,RELA,ARRB1,ARRB2,BTRC,CAPN1,CAPN2,CDC34,CHUK,COMMD1,COPS8,CSNK2A1,CUL1,DYNLL1,EIF2AK2,FBXW11,G3BP2,HDAC1,HDAC3,HNRNPA1,HOXA9,HOXB7,HSPB1,IKBKAP,IKBKB,IKBKE,IKBKG,JAK2,LCK,MAP3K2,MAP3K3,MCM5,MCM7,MED19,NCOR2,NFKB1,NFKB2,NFKBIB,NKIRAS1,NKIRAS2,PIK3R1,POM121,PRKCI,PTPN1,PTPN13,REL,RELA,RPS6KA1,SKP1,SLC25A4,SLC25A5,SRC,SUMO1,SUMO4,TBK1,TNFSF11,TP53,TUBA1B,UBE2D2,UBE2D3,UBE2E3,VCP,AURKA,BARD1,BTRC,CAPN1,CHUK,COMMD1,DYNLL1,FBXW11,G3BP2,HNRNPA1,HOXB7,IKBKAP,IKBKB,LYL1,MAP3K14,MED19,NCOR2,NFKB1,PIK3R1,PIR,POM121,PTPN13,REL,RELA,RPS6KA1,SUMO4,TP53,UBC,UBE2D1,UBE2E3,VCP
Quality control The peptide is characterized by mass spectroscopy
Key reference Janssen,R., et al., (2004) J. Exp. Med. 200 (5), 559-568
Description This is a synthetic peptide designed for use in combination with anti-NFKBIA antibody (Catalog #: P100940_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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