Sku |
AAP31273 |
Old sku |
AAPP02022 |
Price |
$99.00 |
Name |
E2F5 Peptide (AAP31273) |
Purchase info |
To purchase this peptide:
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|
Size |
100 ug |
Gene |
E2F5 |
Alias symbols |
E2F-5 |
Gene id |
1875 |
Description of target |
E2F5 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It is more homologous to E2F4, a family member, than to other members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. |
Swissprot id |
Q15329 |
Protein accession num |
NP_001942 |
Nucleotide accession num |
NM_001951 |
Protein size |
346 amino acids |
Molecular weight |
38kDa |
Application |
WB |
Partner proteins |
BIRC5,MT1G,MYC,RBL2,TFDP1,CREBBP,EP300,RBL1,RBL2,SMAD3,TFDP1,XPO1,BRCC3,RBL1,RBL2,TFDP1 |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Ohtani,N., et al., (2003) J. Cell Biol. 162 (2), 173-183 |
Description |
This is a synthetic peptide designed for use in combination with anti-E2F5 antibody (Catalog #: P100920_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
|
Tips |
See our General FAQ page. |
Availability |
In Stock |