E2F5 Peptide (AAP31273)

Data Sheet
 
Sku AAP31273
Old sku AAPP02022
Price $99.00
Name E2F5 Peptide (AAP31273)
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Size 100 ug
Gene E2F5
Alias symbols E2F-5
Gene id 1875
Description of target E2F5 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It is more homologous to E2F4, a family member, than to other members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB.
Swissprot id Q15329
Protein accession num NP_001942
Nucleotide accession num NM_001951
Protein size 346 amino acids
Molecular weight 38kDa
Application WB
Partner proteins BIRC5,MT1G,MYC,RBL2,TFDP1,CREBBP,EP300,RBL1,RBL2,SMAD3,TFDP1,XPO1,BRCC3,RBL1,RBL2,TFDP1
Quality control The peptide is characterized by mass spectroscopy
Key reference Ohtani,N., et al., (2003) J. Cell Biol. 162 (2), 173-183
Description This is a synthetic peptide designed for use in combination with anti-E2F5 antibody (Catalog #: P100920_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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