E2F1 Peptide - N-terminal region (AAP31170)

Data Sheet
 
Sku AAP31170
Old sku AAPP01913
Price $99.00
Name E2F1 Peptide - N-terminal region (AAP31170)
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Size 100 ug
Gene E2F1
Alias symbols E2F-1, RBBP3, RBP3, RBAP1
Gene id 1869
Description of target The protein encoded by E2F1 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot id Q01094
Protein accession num NP_005216
Nucleotide accession num NM_005225
Protein size 437 amino acids
Molecular weight 47kDa
Application WB
Partner proteins E2F2,E2F4,RBL2,BARD1,BIRC5,BRCA1,CBX5,CCDC76,CCNA1,CCNA2,CDC25A,CDC6,CDK1,CDKN2A,CEBPD,CEBPE,CHEK1,CSDA,E2F1,EAPP,FHL2,GAB2,GAS2L1,HIST1H2AG,HIST1H2BJ,HIST2H4A,JMY,MAD2L1,MAD2L1,MDM4,MFAP1,MLH1,MSH2,MSH2,MT1G,MYBL2,MYC,NCOA3,PPP1R13B,PPP1R13B,PRR11,RAD51,RAD54L,RB1,RB1,RB1,RB1,RB1,RB1,RBL1,RBL2,RECQL,TFDP1,TP53BP2,TP53BP2,TP53INP1,TTK,TYMS,UXT,ARID3A,ATM,ATR,BRCA1,BRD2,CCNA1,CCNA2,CDK1,CDK3,CDK7,CDKN2A,CEBPE,CHEK2,CREBBP,CTDP1,CUL1,DDB2,E2F6,GTF2H1,KAT5,MDM4,MNAT1,NCOA3,NCOA6,NDN,NFKB1,NPDC1,PARP1,PHB,PURA,RB1,SERTAD2,SKP2,SP1,SP2,SP3,SP4,TFDP1,TFDP2,TOPBP1,TP53,TP53BP1,TRRAP,ARID3A,BRD2,CCNA1,CCNA2,CDK2,CDK7,CDT1,CREBBP,CUL1,DNMT1,FHL2,GSK3B,GTF2H1,HDAC1,MDM4,MGA,MYBL2,NCOA6,NDN,NDNL2,NFKB1,NPDC1,Nfkb1,PHB,PKIB,PURA,RB1,RBBP4,RBL1,RING1,RNF144A,SKP2,SP1,SP2,SP3,SP4,SPIB,Sp1,TEAD3,TFDP1,TFDP2,TOPBP1,TP53BP1,TRRAP,UBC
Quality control The peptide is characterized by mass spectroscopy
Key reference Hu,Y., (2008) Biochem. Biophys. Res. Commun. 370 (3), 440-444
Description This is a synthetic peptide designed for use in combination with anti-E2F1 antibody (Catalog #: P100821_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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