| Sku |
AAP31159 |
| Old sku |
AAPP01902 |
| Price |
$99.00 |
| Name |
RUNX1 Peptide - middle region (AAP31159) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
RUNX1 |
| Alias symbols |
AML1, AML1-EVI-1, AMLCR1, CBFA2, EVI-1, PEBP2aB |
| Gene id |
861 |
| Description of target |
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. RUNX1 is the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with severaltypes of leukemia. Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. |
| Swissprot id |
B2RMS4 |
| Protein accession num |
NP_001745 |
| Nucleotide accession num |
NM_001754 |
| Protein size |
480 amino acids |
| Molecular weight |
52kDa |
| Application |
WB |
| Partner proteins |
CBFB,TLE1,CBFB,TLE1,AR,CBFA2T2,CBFA2T3,CBFB,CCND1,CCND2,CCND3,CDK6,CEBPA,CEBPB,ELF2,ELF4,EP300,FOS,FOXP3,HIPK1,HIPK2,JUN,MYST3,MYST4,NCOR2,PAX5,SUV39H1,TLE1,TLE2,WWTR1,YAP1,AES,CBFA2T2,CBFB,CEBPB,EFNA2,ELF2,ELF4,ETS1,FHL2,FOS,JUN,LEF1,MYOD1,MYST4,PAX5,SMAD1,SMAD2,SMAD3,SMAD5,SUV39H1,TLE1,TRAF6,VDR,YAP1 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Takeshita,M., (2008) Leukemia 22 (6), 1241-1249 |
| Description |
This is a synthetic peptide designed for use in combination with anti-RUNX1 antibody (Catalog #: P100877_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
